Latency and lytic replication in Epstein–Barr virus-associated oncogenesis
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چکیده
منابع مشابه
The latency-associated nuclear antigen homolog of herpesvirus saimiri inhibits lytic virus replication.
Herpesvirus saimiri (HVS), a T-lymphotropic tumor virus of neotropical primates, and the Kaposi's sarcoma-associated human herpesvirus 8 (KSHV) belong to the gamma-(2)-herpesvirus (Rhadinovirus) subfamily and share numerous features of genome structure and organization. The KSHV latency-associated nuclear antigen (LANA) protein appears to be relevant for viral persistence, latency, and transfor...
متن کاملSifting and Winnowing through Human Cytomegalovirus Lytic Replication and Latency
My love of nature began in the field, forest, and creek behindmy house where I spent my summer days catching butterflies, salamanders, minnows, and toads. In high school, the logic and irrefutability of geometry proofs turnedme into a rational thinker. College steered me towards molecular biology. Graduate school introducedme to the art of generating data. My mentor, Joyce Hamlin, and the great...
متن کاملKaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus-mediated control of latency.
Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV, also designated human herpesvirus 8) can establish a latent infection in the infected host. During latency a small number of genes are expressed. One of those genes encodes latency-associated nuclear antigen (LANA), which is constitutively expressed in cells during latent as well as lytic infection. LANA has previously bee...
متن کاملActivity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein-Barr virus associated disorders.
BACKGROUND/AIMS In Epstein-Barr virus (EBV) positive cell lines that are stably infected, three different promoters are known to direct the transcription of EBV nuclear antigen 1 (EBNA1). These are located in the BamHI-C, BamHI-Q, and BamHI-F regions of the viral genome (Cp, Qp, and Fp, respectively). Fp is activated upon induction of the viral lytic cycle. The aim of this study was to investig...
متن کاملK13 Blocks KSHV Lytic Replication and Deregulates vIL6 and hIL6 Expression: A Model of Lytic Replication Induced Clonal Selection in Viral Oncogenesis
BACKGROUND Accumulating evidence suggests that dysregulated expression of lytic genes plays an important role in KSHV (Kaposi's sarcoma associated herpesvirus) tumorigenesis. However, the molecular events leading to the dysregulation of KSHV lytic gene expression program are incompletely understood. METHODOLOGY/PRINCIPAL FINDINGS We have studied the effect of KSHV-encoded latent protein vFLIP...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2019
ISSN: 1740-1526,1740-1534
DOI: 10.1038/s41579-019-0249-7